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Five Offprints on the Transgenic Mouse
, 1981-98. 1981-98. Somatic Expression of Herpes Thymidine Kinase in Mice Following Injection of a Fusion Gene Into Eggs (Cell 27:332-231, 1981); Regulation of Methallothionein-Thymidine Kinase Fusion Plasmids Injected Into Mouse Eggs (Nature 296:39-42, 1982); Dramatic Growth of Mice that Develop from Eggs Microinjected with Methalliothionein-Growth Fusion Genes (Nature 300:611-615, 1982); Methalliothionein-Human GH Fusion Genes Stimulate Growth of Mice (Science 222:809-814, 1983); Transgenic Mice – The Early Days (Int. J. Dev. Biol. 42:847-854, 1998). 5 offprints, of which 4 are staple bound in original self-wraps. 1 offprint with original colour pictorial wrappers. Fine condition. Offprints of five papers on the development of the transgenic mouse, one of the most important lines of research in 20th-century biotechnology. The first four offprints in this group are key technical papers in the development of transgenic mice, and the fifth is a short memoir by Palmiter in which he warmly recounts his partnership with Brinster and their work in this important field. In 1974 Rudolf Jaenisch created the world's first transgenic organism – a creature whose genome incorporates and uses genetic material from another species – by injecting retroviral DNA into a mouse embryo. The DNA was then shown to be present in every cell of the mouse's body, but was not passed on to the mouse's offspring, and other scientists around the world continued this line of research. Before working on transgenic mice the authors of the present offprints, Palmiter and Brinster, both made major contributions to embryology and genetics. In the 1960s Brinster developed the first reliable in vitro culture system for mammalian embryos, which is today the basis for all transgenic, stem cell, cloning, and in vitro fertilisation technologies, and he introduced methods for injecting DNA, RNA, and stem cells into embryos. Palmiter made advances in understanding gene transcription, the process by which proteins are created from a cell's mRNA template, specialising in the synthesis of egg white protein and a protein called methallothionein, which binds toxic heavy metals. In 1979 the two researchers began corresponding when Brinster requested a sample of chicken mRNA from Palmiter's lab – he was hoping to inject it into mouse oocytes to see if the cells would incorporate it and begin transcribing the egg white protein. From there they embarked on a fruitful partnership that would culminate in their creation in 1982 of the world's first transgenic animals that could pass their new genes to offspring, first mice, then rabbits, sheep, and pigs. The team's transgenic mice initiated a biotechnology revolution. They not only demonstrated the feasibility of stable genetic engineering in mammals, but because their genomes could be precisely controlled, they could be used to study huge numbers of other scientific issues. Palmiter and Brinster created thousands of transgenic mice to study the effects of different genes, and the techniques they pioneered have led to breakthroughs in understanding Alzheimers, diabetes, hepatitis, and cancer. Most famously, in 1983 they incorporated a rat growth hormone gene into the mouse genome, creating "Mighty Mice" that grew to twice their normal size and passed the genes on to their offspring. An image of a Mighty Mouse next to a normal mouse appeared on the cover of Science in 1983, and the associated offprint present in this group, "Methalliothionein-Human GH Fusion Genes Stimulate Growth of Mice", has covers which reproduce that classic image. A wonderful set of rare offprints.
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Last Found On: 2014-03-24           Check availability:      Biblio    

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