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Nova et tuta variolas excitandi per transplantationem methodus; nuper inventa & in usum tracta: qua rite peracta, immunia in posterum praeservantur ab huiusmodi contagio corpora.
Venice, Giovanni Gabriele Hertz, 1715 - 8vo (142 x 92 mm), pp 33 [3, blank], with woodcut device on title; a fine, unpressed copy, outer edges uncut, in marbled wrappers, in a morocco-backed box.First edition of the exceptionally rare foundation work in immunology, the first book in Europe not only to describe the inoculation process but to base it on empirical evidence. 'Pilarino in 1701 inoculated three children at Constantinople with smallpox virus. He is accredited with the "medical" discovery of variolation, and thus is the first immunologist. His book records his many researches on the subject' (Garrison-Morton). The full title of this work translated as 'New and safe method to stimulate smallpox by inoculation, recently invented and put into practice and performed routinely, by which bodies acquire immunity against this infection in later years'.'In the eighteenth century another even more important event took place for the future immunology. The variolation, that is, the first immunizing method, was introduced in Europe. . 'Western European medicine first considered variolation as a vulgar and useless way of preventing smallpox. But the Venetian physician Jacobo Pylarino (1659-1718), who travelled in different parts of Asia and Africa, learned the technique. In 1701 he settled in Constantinople and there, for the first time in Europe, inoculated with smallpox virus the three children of a friend. Afterwards, he devoted himself for studying the method and published in 1715 in the Latin language a book entitled Nova, et tuta variolas excitandi per transplantationem methodus; nuper inventa et in usum tracta: qua rite peracta, immunia in posterum preservantur ab hujusmodi contagio corpora. As we can see, the title includes the term immunia (referred here to corpora, i.e., "a method by which the bodies become immune to contagion"), so Pylarino recovered in his book the antique word and revived it for the future. A summary of the book was translated into English and presented to the Royal Society .'It is remarkable, however, that the recovery of the term immunity (passive exemption) in this period was due to a relatively modern physician such as Pylarino at a time when he was presenting an active method to protect against a disease, too far distant from a magical idea of causation. Perhaps it occurred through respect for tradition or perhaps there is another explanation. It's possible that the reappearance of the term "immunity" around this time was accompanied, as the Spanish philologist E. PingarrĂ³n recently suggested, by a cross between the terms imm nitat e imm nire, the latter phrase being a classic Latin military term meaning "to defend from inside". It is possible that Pylarino, literate in Latin, kept this in mind when using the old term and that this combined in the new and future uses of imm nitas' (Juan Manuel Igea, 'From the Old Immunitas to the Modern Immunity', Current immunology Reviews vol 11 n 1 (2015) p 59).Pilarino's work was preceded by a letter sent to the Royal Society by Emanuel Timone at Constantinope; it prompted an investigation by the secretary Richard Waller, who contacted the botanist Dr William Sherard, then serving as British Consul in Smyrna. Sherard in turn consulted his friend Pilarino, who provided him with details of the Ottoman inoculation technique, its safety, and of his own successful experimentation with inoculation. Sherard later sent a copy of Pilarino's book, which is dedicated to Sherard, to the Royal Society, where a summary was published, along with excerpts from Timone's letter on inoculation in the Philosophical transactions (v 29, pp 393-9, 1716).'Following the publication of Timone's account, and of a small volume on the same theme by Pylarino in 1715, knowledge of the method slowly spread throughout Europe and the newly established colonies on the other side of the Atlantic. In spite of the helpful publicity engineered by various factions of scoiety led by Lady Mary Wortley Montague, Voltaire, and the Princess of
      [Bookseller: WP Watson Antiquarian Books]
Last Found On: 2017-02-28           Check availability:      IberLibro    

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