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Ueber Zelltheilung in der menschlichgen Epidermis.
Festschrift Rudolf Virchow zu seinem 71. Geburtstage. - Berlin, Georg Reimer, 1891, Gr.4, 11, (1) pp., 1 lith. Taf., marmor. Pappbandmit eingebundener orig. Broschur. First Edition! Cell division in the human epidermis:"This is an account of mitoses in the human epidermis. Under normal conditions, mitoses are relatively sparse and almost always located in the basal layer of the epidermis. In atrophic conditions of the epidermis, there are fewer mitoses, and in inflammatory and hyperplastic diseases the numbers of mitoses increase, and they can occur in levels above the basal layer. The morphology of the mitoses is generally similar to mitoses in other tissues.There is a discussion of whether the mitoses in the epidermis under normal conditions should be considered "pathological" in the sense of being continuously provoked by the exposure of the uppermost epidermis to harmful environmental influences.Then Hansemann discusses the role of nutritional mechanisms and leukocytes in hyperplastic increases in numbers of mitoses, and also the nature of differentiation and "physiological cell death" in the fate of epidermal cells. The summary (p. 12 of original) is straightforward:"If we now briefly summarise the above observations, the following are the results:1.The mitoses, which are always present in the epidermis, are the expression of a pathological process evoked by direct harmful influence of the external world.2.Cell division leads to a multi-layered quality of the epidermis, and the keratinisation of the cells is conditioned by this.3. Only the lowermost layer of the rete Malpighi is to be designated as a germinal layer. Under pathological conditions the germinal layer may disappear infrequently - more frequently it is considerably broadened - and this process gives the epidermis its stamp in each case"." Leon Bignold, et al.: David Hansemann: Contribution to Oncology, 278-279
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