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Sulle cellule globulifere del midollo delle ossa. Nota del Dott. G. Bizzozero.
Gazetta Medica Italiana - Lombario, N.24, anno 1869, 8, (3, (1) pp. mit Stempel von Prof. Dr. Alexander Rollett". Extrem rare offprint! "In una comunicazione preventiva del Prof. E. Neumann pubblicata nel 'Centralblatt f. med. Wissensch. Del 17 aprilee risguardante alcune alterazioni patologiche del midollo si contengono le seguenti linee. 'La formazione nel midollo di cellule che contengono glubluli rossi non è (contro la opinione di Bizzozero) .""Haematopoiesis in the bone marrow. Before his graduation, Bizzozero began to investigate the histology of bone marrow. At that time, there were two main views on the functions of this tissue, which dated back to the ancient time of Hippocrates and Aristotle. According to these views, the bone marrow either constituted an 'excrement' of the bone (excrementum ossium), or, on the contrary, it represented its nutritional 'matrix'. Bizzozero discovered a particular kind of nucleated red cell in this tissue, and he considered these cells to be the precursors of the mature red cells of the circulating blood. Moreover, he realized that bone marrow is the site of production of white blood cells and also exerts a role, like the spleen, in the destruction of old cellular elements. Bizzozero's conclusions were confirmed by experiments of bleeding under controlled conditions, carried out on chickens and pigeons, which amplified the blood-cell-forming phenomenon in bone marrow.The finding that bone marrow was able to produce blood was also made at the same time by the Prussian haematologist Ernst Neumann, a professor at the University of Königsberg, who published part of his results in 1868, a month before the Italian researcher." Paolo Mazzarello, Alessandro L. Calligaro & Alberto Calligaro: Timeline: Giulio Bizzozero: a pioneer of cell biology. Nature Reviews Molecular Cell Biology 2 (2001/10), pp.776-784
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Last Found On: 2017-09-23           Check availability:    


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