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Sulla struttura delle ghiandole linfatiche.
Inernat. Monatsschr. f. Anatom. u. Histologie, Bd. II. 1885. - 1885, 8, pp.278-283, 1 lith. Taf. mit eigenhändiger Anschrift an "M. le Prof. L. Ranvier. Collegè de France, Paris.", Briefmarken, Poststempel v. 3.9.85. Extreme rare Offprint!"In 1873, Bizzozero even hinted at the role exerted against infection by connective reticular phagocytes of lymph nodes. In a study on the structure of lymphatic glands, he stated that reticular cells could ingest infective particles that were carried by the lymphatic liquid. He added that: "...this fact is, perhaps, the cause of the stoppage of some infections to the lymphatic glands which are connected to the part covered by the infection through the lymphatic vessels" *). So, the mechanism of phagocytosis as a biological phenomenon was precisely described by Bizzozero in the period between 1871 and 1873, more than 10 years before Elie Metchnikoff described it. However, if we consider a structured 'theory' or 'doctrine' of phagocytosis that is, a theory or doctrine of immunity, this implies a mechanism of defence from external biological aggression that could be fully proposed only after the microbiological discoveries of Louis Pasteur and Robert Koch. And this concept was structured and articulated by Metchnikoff from 1882 onwards. However, the great Russian founder of immunology never sought credit for being the first to describe the phenomenon of phagocytosis, and in his masterpiece Immunity in Infective Diseases gave full credit to Bizzozero for having " ...first recognized ... an amoeboid cell which had ingested pus corpuscles". " Paolo Mazzarello, Alessandro L. Calligaro & Alberto Calligaro: Timeline: Giulio Bizzozero: a pioneer of cell biology. Nature Reviews Molecular Cell Biology 2 (2001/10), pp.776-784*) Bizzozero G. Studi sulla struttura delle ghiandole linfatiche. Giornale della R. Accad. Med. Torino 13, 132-144 (1873). **) Metchnikoff, E. Ueber eine Sprosspilzkrankheit der Daphnien. Beitrag zur Lehre über den Kampf der Phagocyten gegen Krankheitserreger. Archiv. Path. Anat. Physiol. Klin. Med. 96, 179-195 (1884).
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