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Nucleotide Sequences in the Low Molecular Weight Ribosomal Ribonucleic Acid of Escherichia Coli.
Cambridge: Emmanuel College,, 1967. A dissertation submitted to the University of Cambridge for examination for the degree of Doctor of Philosophy. Large octavo. Original black cloth, spine lettered in gilt. Typescript, text mainly on the rectos. 46 pages of plates, some tipped-in and others full-page. Dampstain to rear board and some slightly affecting top edges of contents, other occasional spotting and some creasing of leaves with tipped-in plates, a very good copy. The doctoral dissertation of distinguished molecular biologist George Gow Brownlee. Inscribed by the author to his supervisor Frederick Sanger on the front free endpaper, "To Fred, from George, May 1967". Brownlee completed this dissertation on sequencing E. coli RNA under Sanger's guidance at the Laboratory of Molecular Biology and went on to have a successful career studying DNA and RNA sequencing and the genetics of hemophilia and influenza, making key discoveries in each of these areas. In the 1970s his research group was responsible for the important discovery of pseudogenes, now known to be a key part of all organisms' genetic material. He was responsible for developing a laboratory method of producing blood clotting factor IX for patients with haemophilia B, reducing their reliance on blood-derived products, and he currently studies gene regulation in influenza, work that "may have implications for the development of novel influenza vaccines in the future" (Lincoln College biography). In 2014 Brownlee published the first full biography of his former mentor, Fred Sanger: Double Nobel Laureate.
      [Bookseller: Peter Harrington]
Last Found On: 2017-08-22           Check availability:      Biblio    

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